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Molecular hydrogen (H2) or diatomic hydrogen is a tasteless, odourless, flammable gas. H2 studies have focused on its role in reduction of oxidative stress and redox homeostasis partly mediated via the Nrf2 pathway, which regulates levels of glutathione, superoxide dismutase, catalase, etc. H2, like other gaseous-signaling molecules (e.g. NO*, CO, H2 S), modulates signal transduction, protein phosphorylation, and gene expression, which provides its anti-inflammatory, anti-allergy, and anti-apoptotic protective effects.
Not in the strict definition of an antioxidant, but instead plays a role in signalling. Although the research is early, the 500+ scientific articles have suggest that H2 has therapeutic potential in over 170 different human and animal disease models, and essentially every organ of the human body. Hydrogen is the first element in the periodic table which is also extremely reactive, bonding with another hydrogen molecule as soon as one is available to form hydrogen gas (H2). Being the small element means that it can get everywhere in your body when ingested including through the cell membrane, the blood brain barrier, mitochondria cells and even into a cell’s nucleus.
How does hydrogen differ to other antioxidants?
Hydrogen has a natural property which enables it to dissolve into and move across cell membranes, so it can get into any compartment of our body. Hydrogen is different to other antioxidants which cannot do this. A good example is the central nervous system, which has a barrier called the blood brain barrier to prevent molecules from getting into the brain, and hydrogen can do this which shows how effective it is as getting through the cell nucleus.
Some antioxidants are so strong that they can suppress all oxidants within the cell and research show that is not good for cell signalling and gene regulation, so those processes should not be affected. Hydrogen does not affect these processes and instead targets the oxidation of the cell. Several studies are available for hydrogen rich water and its role in anti-aging, from exercise recovery and several other therapies. Hospitals offering hydrogen therapy have opened all over the developed world and now we have bottle and jug systems to make this water for us.
So how do I take Molecular Hydrogen?
Osmio supply hospitals which specialize in using the intravenous injection of hydrogen-rich saline for intensive therapy to people. The great news is now, there are products which you can use at home, the three main types are:
1) Drinking Hydrogen Rich Water - Hydrogen rich water is produced in two main ways - a) Using electrolysis (i.e. in a water bottle) or b) using hydrogen generating tablets containing elemental pure magnesium and malic acid. Another way is currently under development using calcium hydroxide.
2) Inhalation of Hydrogen Gas - For inhalation, a 2-4% hydrogen gas mixture is common because it is below the flammability level; however, some studies use 66.7% H2 and 33.3% O2, which is nontoxic and effective, but flammable. Inhalation of hydrogen reaches a peak plasma level (i.e. equilibrium based on Henry’s Law) in about 30 min, and upon cessation of inhalation the return to baseline occurs in about 60 min.
The pharmacokinetics of each method are still under investigation, but are dependent on dosage, route, and timing.
Browse the Osmio Hydrogen Product Range below and please do contact us with your questions.
Unit 2B, Beechcroft Farm Industrial Estate, Ash, Kent TN15 7HX
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